For this purpose, linear and logistic regression ...

Emphysema is smoking caused lung condition. Genetically caused differences in metabolic enzymes, oxidative agents that are supposed to modify individual susceptibility to emphysema and other smoking related, pulmonary diseases. We investigated whether polymorphisms in specific genes, xenobiotics metabolism enzymes predisposes emphysematous changes and airflow lasix 40 mg limitation between Finnish Caucasian builders. PCR method was used for the analysis of nine common polymorphisms in EPHX1, GSTM1, GSTM3, GSTP1, GSTT1 and NAT2 gene in 988 Finnish builders. Genotype data were compared with different signs emphysematous confirmed by high resolution, computerized tomography and forced lung capacity and forced expiratory volume in 1 s. For this purpose, linear and logistic regression analysis, taking into account potential interfering factors were used. EPHX1 Tyr113His polymorphism is associated with changes emphysematous (P = 0. 007), including paraceptal (P = 0. 039), panlobular (P = 0. 013), and bull (P = 0. 003) type changes. GSTM3 promoter polymorphism of the gene was associated with forced expiratory volume in 1 s / forced vital capacity ratio (P = 0. 010) and GSTT1 genotype with emphysematous signs (P = 0. 008), including paraceptal (P = 0. 015), panlobular (P = 0. 031), and Bull-type (P = 0. 045) changes. Further analysis, GSTT1 deletion was present twice the overall risk of the presence of emphysema changes (odds ratio: February 1, 95% confidence interval: .. 1. 33-3 03), and nearly four times the risk for having serious changes in emphysematous (odds ratio: 3 70, 95% confidence interval: .. 2. 6.15 36). The results indicate a significant change in the role of GSTT1 gene polymorphism in individual risk and severity of emphysema changes. .